In the cutting-edge research and trial production fields of pharmaceuticals, cosmetics, and food industries, the oral dissolution film making machine (laboratory type) is becoming the core engine for innovative film formulation development with its unparalleled precision and flexibility. The core mission of this type of professional equipment is to apply liquid or semi liquid raw materials (such as drug solutions containing active ingredients, functional solutions, or food grade slurries) with excellent uniformity onto a specific base film, undergo precise drying and curing processes, and ultimately produce thin film materials with controllable thickness and consistent performance. In order to meet diverse research and development needs, modern laboratory models can usually integrate key post-processing units such as lamination (composite multi-layer functional film) and slitting (customized size and shape) to form a complete thin film trial production platform.
Beyond tradition: the core advantage of laboratory type film making machines
Compared to medium and large-scale production equipment or manual preparation, laboratory type oral dissolution film making machines have demonstrated irreplaceable core values in the research and development stage:
Unparalleled coating accuracy and uniformity control:
Micron level control: Advanced technologies such as high-precision metering pumps, slit coating heads, or Mayer rods are used to achieve precise control of coating thickness (usually ranging from tens to hundreds of micrometers). This stability is crucial for products such as oral dissolution membranes that require rapid and uniform release of active ingredients, directly affecting their disintegration time, taste experience, and efficacy.
Eliminating edge effects: The precise coating system design ensures consistent thickness across the entire film surface (especially in the edge area), effectively avoiding common coating unevenness, stripes, or "edge thickening" phenomena in traditional methods, and ensuring highly reproducible performance of each film.
Low load coating capability: Particularly adept at handling formulations with low viscosity or requiring extremely thin coatings (such as certain highly active drugs or transdermal patch backing layers), which are difficult to achieve stably with large equipment or manual operations.
Powerful independent control capability of process parameters:
Refinement of drying process: equipped with multiple independent temperature controlled drying tunnels (such as infrared, hot air, or a combination of both), accurately controlling the temperature, wind speed, and time of each drying stage. This is particularly critical for formulations containing thermosensitive ingredients (such as peptides, probiotics) or complex solvent systems, which can effectively prevent the deactivation of active ingredients, surface crust or bubble formation, optimize the physical and mechanical properties (such as flexibility, tensile strength) and dissolution characteristics of the membrane material.
Tension and speed coordination: Precise control of the bottom film transmission tension and coating line speed ensures that the entire process of coating, drying, and winding the film material is smooth without wrinkles or stretching deformation, laying the foundation for subsequent lamination, slitting, and packaging.
Excellent guarantee for solvent residue control:
Targeted drying design: In response to the pain point emphasized by users that "residual solvent levels must meet strict limits", laboratory models optimize the drying chamber structure (such as adding air nozzles, extending drying paths), accurately control the drying curve (heating/cooling rate, temperature of each section), and can choose online or offline solvent residue monitoring interfaces to ensure that even complex formulas (such as high boiling point solvents or mixed solvent systems) can efficiently and thoroughly remove solvents. The final product strictly meets the strict requirements of ICH, GMP and other regulations for solvent residues, ensuring the safety and stability of the product.
Flexible and efficient small batch research and conversion:
Minimizing material consumption: Designed specifically for small-scale (from a few grams to a few kilograms of raw materials) trial production, it greatly saves the amount of expensive active pharmaceutical ingredients (APIs) or special excipients, accelerates formula screening and iteration processes, and significantly reduces research and development costs.
Rapid iteration of formula and process: easy to switch between different base films (such as PET, HPMC, water-soluble polymer films), coating head types, and process parameters. Researchers can quickly evaluate the impact of various formula designs, auxiliary material combinations, and process conditions on film quality.
Seamless scaling up production: The formula and process parameters (such as viscosity coating speed relationship, drying curve) successfully validated on a laboratory scale can provide a solid and reliable data foundation and process window guidance for subsequent pilot scale scaling up and industrial production, significantly reducing technology transfer risks and shortening product launch cycles.
Multi functional integration expands research and development boundaries:
One stop "film forming: The integrated lamination module allows for the preparation of multi-layer composite films (such as transdermal patches with drug containing layer/adhesive layer/backing layer structure, or functional barrier films) on a single device. The integrated slitting module can directly produce final samples of the required size and shape (strip, square, circular) for subsequent stability testing, in vitro dissolution/release studies, sensory evaluation, or early clinical research.
The precision and flexibility of the laboratory type oral dissolution film making machine make it shine in multiple cutting-edge fields:
Pharmaceutical industry:
Oral Dissolving Film (ODF): This is the most essential application. Innovative forms of administration for children, elderly, or patients with swallowing difficulties, such as antiemetic drugs, painkillers, psychotropic drugs, vitamin supplements, etc. The equipment ensures rapid disintegration of the membrane, suitable taste, and precise dosage.
Transdermal patch: precisely coating drug containing matrix layer (pressure sensitive adhesive, gel), adhesive layer or controlled release film layer; The lamination function enables the assembly of multi-layer composite structures.
Mucosal adhesive preparations: Develop long-lasting or local therapeutic films for mucosal areas such as the oral cavity, eyes, nose, and vagina (such as oral ulcer films, periodontitis slow-release films, vaginal antibacterial films).
New drug delivery system: microneedle array patch substrate coating, soluble microencapsulation film, personalized dose film.
Cosmetics and Personal Care:
Soluble essence facial mask/eye mask: prepare water-soluble or peelable film containing high concentration of active ingredients (such as peptides, vitamins, plant extracts) to provide efficient and convenient skin care experience.
Oral care film: Whitening film, breath freshener film, antibacterial film, etc., directly attached to teeth or gums.
Innovative patches: Acne patches, local light patches, post hair removal soothing patches, etc., can integrate adhesive and functional layers.
Exploration of Functional Packaging Films: Study soluble/degradable packaging materials containing active ingredients such as antioxidants and moisturizing factors.
Food industry:
Edible packaging film: Develop environmentally friendly edible films based on sodium alginate, chitosan, starch, etc. for food inner packaging or coating.
Functional food film: a soluble film strip containing vitamins, minerals, probiotics, and flavor substances (such as energy films, nutrient enhancing films, and breath freshener sugar substitutes).
Food decoration and coating: precision coated edible pigments, flavor coatings, or removable protective films.
New food forms: Explore special food forms such as CBD/nutrient enhanced films.
The oral dissolution film making machine (laboratory type) is no longer a simple coating equipment, it is a high-end research and development platform that integrates precision mechanical engineering, materials science, and process control technology. Its significant advantages in coating uniformity, process controllability (especially strict solvent residue control), small batch flexibility, and multifunctional integration make it an indispensable core tool in the development of front-end film dosage forms such as patches, oral soluble film strips, and mucosal adhesives in the pharmaceutical, cosmetics, and food industries. In today's pursuit of personalized medicine, green packaging, and convenient and efficient product experience, laboratory type film making machines are continuously empowering researchers to break through the limits of formulas and processes, accelerating the transformation of more safe, effective, and convenient innovative film products from laboratory concepts to reality, benefiting the improvement of human health and quality of life.
Post time: Jun-13-2025